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Formulation, Development and Evaluation of Solid Self Emulsifying Drug Delivery System (S-SEDDS) For Pediatric Patients
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| Author:
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KIRAN C.MAHAJAN, DR.SMITA S.PIMPLE, HEMANT A.DEOKULE
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| Abstract:
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The objective of the present study was to prepare and evaluate solid self-emulsifying drug delivery system (SSEDDS) containing Praziquantel, a poor water-soluble drug. The central composite design was employed to
optimize the formulation variables, Capmul MCM (oil), Cremophore RH40 (surfactant) and PEG400 (cosurfactant). Liquid self-emulsifying drug delivery system was appraised for determination of self emulsifying
time, globule size and drug release. TEM study confirmed the uniform oil globules of the optimized liquid
formulation. The optimized liquid formulation was formulated into free-flowing powder (S-SEDDS) by
adsorption on the materials like Aerosil 200, Neusilin US2 and compressed into tablets. The solid state
characterization of S-SEDDS powder was performed by using DSC, PXRD and SEM to investigate the physical
nature of the drug. Further, the accelerated stability studies for 6 months revealed that S-SEDDS of
Praziquantel was found to be stable without any significant change in physico-chemical properties. S-SEDDS of
Praziquantel with improved dissolution profile was successfully prepared by using Neusilin US2 as an adsorbent
carrier.
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| Keyword:
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Praziquantel (PZQ), Solid-self emulsifying drug delivery system (S-SEDDS), Solid-state characterization, Paediatric patients, Stability.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.335
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| Download:
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