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Exchangeable Ion and its Pharmaceutical Importance
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UPLOADED BY-ADMIN, ALPANA RAM, SHAILENDRA WASNIK, POONAM PARMAR, ASHOK K. SAHOO, NARENDRA PATREY, RAJENDRA SINGH RATHORE
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| Abstract:
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Ion exchange resins are water insoluble, cross linked porous polymer containing inorganic functional group which
may be replaced with ion or drug having same charge. Ion exchange resins have received considerable attention in the development
of controlled and sustainable release system because of their better drug retaining property to form ion exchange
resin-drug complex which when coated with semi-permeable membrane may prevent dose dumping and drug leaching during
storage resulting improved stability. Moreover, ion exchange resin-drug complex can also be used as drug reservoir from
which drug is released by exchanging with ion in gastro intestinal fluid followed by drug diffusion resulting in slow release
but somewhat faster as compared with encapsulated drug resinate. Due to their physical stability, inert nature, uniform size,
spherical shape assisting coating and equilibrium driven drug release, ion exchange resin can be used as flexible drug delivery
vehicle to design a variety of modified release systems such as micro particles, beads, liposomes, liquids, suspension,
simple matrices etc. Ion exchange resins can also be used to overcome various pharmaceutical formulation problems including
bitter taste, poor stability, deliquescence and poor dissolution of drug.
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| Keyword:
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Exchangeable Ion, Counter Ion, Cross Linking, Drug-Resin Complex, IER
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