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Phytochemical and Pharmacological Properties of Bruguiera gymnorrhiza Roots Extract
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| Author:
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UPLOADED BY-ADMIN, M.A RAHMAN, ARIF AHMED, IZ SHAHID
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| Abstract:
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Phytochemical analysis of the dried roots of Bruguiera gymnorrhiza (L.) (Family: Rhizophoraceae) indicated the presence
of flavonoids, reducing sugars, gums, saponins and tannins. The pharmacological interest of these compounds, coupled
with the use of this plant in traditional medicine prompted the authors to check for its possible antinociceptive, antidiarrhea l
and GI motility tests in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing
in mice at the oral dose of 250mg/kg and 500 mg/kg body weight (P < 0.001) comparable to the standard drug diclofenac
sodium at the dose of 25 mg/kg of body weight. When tested for its antidiarrheal effects on castor oil-induced diarrhea in
mice, it increased mean latent period and decreased the frequency of defecation significantly at the dose of 500 mg/kg body
weight (P < 0.01), comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. Moreover, The extract
also reduced significantly the charcoal induced Gastro Intestinal (GI) motility in mice; decreased the movement of GI
tract in comparison to control animals. The obtained results provide a support for the use of this plant in traditional medicine
and its further investigation
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| Keyword:
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Phytochemical , Antinociceptive, Antidiarrhea l, GI motility, Bruguiera gymnorhiza, Rhizophoraceae
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| DOI:
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