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Antimicrobial and Antioxidant Evaluation of Some Novel Synthesized Pyridazinone Derivatives
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| Author:
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DINESH MEHTA, MINAXI SAINI, RINA DAS
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| Abstract:
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This study presents the synthesis and spectral analysis of novel pyridazinone derivatives. Cyclization reaction of mucochloric acid and semicarbazide hydrochloride in the presence of aqueous ethanol afforded 4,5-dichloro-2H-pyridazin-3-one (1). Novel compounds were synthesized by treating the 4,5-dichloro-2H-pyridazin-3-one (1) with substituted aldehyde and amine derivatives. All synthesized compounds were screened for their in vitro antibacterial, antifungal activities by using the agar cup plate method . The newly synthesized compounds showed antimicrobial activity against all the strains. Compounds 3b and 3c showed very good antifungal activity against candida albicans and Aspergillus niger (minimal inhibitory concentration [MIC] = 12.5 µg/mL). Some compounds showed good activity against Gram (+ve) bacteria and Gram (-ve) bacteria. Antioxidant study was done by using DPPH fee radical scavenging activity. Antioxidant activity assay showed that compound 3b had highest scavenger activity.
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| Keyword:
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Pyridazinone, antibacterial activity, antifungal activity, antioxidant
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| EOI:
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| DOI:
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| Download:
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