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Formulation and Evaluation Considerations of Transdermal Drug Delivery System.
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| Author:
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UPLOADED BY-ADMIN, ASHOK H. BARIA, RAKESH P. PATEL
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| Abstract:
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Transdermal drug delivery systems, also known as ‘‘patches,’’ are dosage forms designed to deliver a therapeutically
effective amount of drug across a patient’s skin. Structural and biochemical features of human skin and those characteristics
which contribute to the barrier function and the rate of drug access into the body via skin play an important role. There are
critically three ways in which a drug molecule can cross the intact stratum corneum: via skin appendages (shunt routes);
through the intercellular lipid domains; or by a transcellular route. For successfully developing a transdermal drug delivery
system, the drug should be chosen with great care. The following are some of the desirable properties of a drug for
transdermal delivery. Basic components of transdermal drug delivery systems are release linear, backing, overlay,
membrane, penetration enhancer and pressure sensitive adhesive. There are some problems with existing technology like
variability in dosing, variation in temperature, physiological stress, skin irritation etc. This systemic review highlights
advantages and disadvantages, basic component, types, problems and evaluation of Transdermal Drug Delivery System.
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| Keyword:
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Transdermal drug delivery systems (TDDS), Patches, Penetration enhancer.
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| EOI:
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| DOI:
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| Download:
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