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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Diuretic effect of Adiantumcapillus and its chemical constituents in hypertensive rats

Author: ROSHNA AZIZ, KAWADIZAYE
Abstract: The present study aims to evaluate the diuretic effect of Adiantumcapillusand some of its chemical constituents in hypertensive rats. Forty-eight rats were split into eight groups. Twelve normal rats were included in the first group; six served as negative controls and six were administered Adiantumcapillus. The second group was comprised of 36 hypertensive rats sectioned into six subgroupswith six rats. The first subgroup functioned as a positive control. The second subgroup was administered an aqueous extract of Adiantumcapillus, while the third subgroup received chlorthalidone. The remaining three groups were administered flavonoids, alkaloids and phenolicsextracted from Adiantumcapillus. Urine output, blood pressure and pulse rate were monitored. The subjects’ glomerular filtration rate, urea and creatinine levels, and serum electrolyte concentration and excretion rates were measured. The results were then compared with results of the standard antihypertensive drug chlorthalidone. It was concluded that Adiantumcapillus administration increased urine flow and the sodium excretion rate and lowered systolic blood pressure in hypertensive rats. Other constituents of Adiantumcapillus, apart from flavonoids, alkaloids and phenolics, could be responsible for these observations.
Keyword: Adiantumcapillus,Flavonoids, alkaloids, phenolics, Diuretic,Hypertensive rats.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.014
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