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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Procaine as a New Coupling Agent for the Spectrophotometric Determination of Fibrates by Diazotization Coupling Reaction

Author: MUTHANA MASHKOUR, MOHAMMED K. KAHLOL
Abstract: A sensitive, selective, rapid , simple and accurate of the spectr?ph?tometricdeterminati?n of fibrates in bulk and in d?sagef?rms. This meth?d depend ?ndiacotization?f primary amine gr?up?f procaine hydrochloric acid with s?dium nitrate and hydr?chloric acid f?ll?wed by c?upling with fibrates in aque?us mildly acidic medium t? f?rmazo dye astable?range –yell?w . Sh?wed obeyed beers law between 0.2- 14 ppm , with molar absorptivity 3.01*104L.mole-1.cm- 1 at 385nm. Sandells sensitivity 0.006mg.cm-1, limit of detection (L?D) 0.018ppm and limit of quantitication (L?Q) 0.058 ppm . This meth?dhas been successfully applied t?determinati?n of fibrates in bulk and in pharmceutical preparation , tablet with agood recoveries 99.63-100.25 % .
Keyword: Procaine hydrochloric acid, Fibrates, Diazotization-coupling, Spectrophotometry.
DOI: https://doi.org/10.31838/ijpr/2019.11.03.034
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