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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Spectrophotometric Determination for Bisacodyl Drug by Oxidative Coupling with Ansidine

Author: IQBAL MOHAMMED, ABDULSALAM A. ABDULKAREEM, SUAD T. ALI
Abstract: An efficient, simple, rapid and economical colorimetric method for specific determination of microgram amounts of bisacodyl in pure and pharmaceutical preparations has been developed. The proposed method is based on an oxidative coupling reaction between bisacodyl and ansidine reagent in presence of Sodiumnitroprusside an oxidant agent in neutral media to form an intense purple color product that has a ? max 542.4 nm. Linearity of calibration graph was observed in the range of (1.00–3.00) µg.ml-1 with molar absorptivity of (14.502 ×103 L.mol-1.cm-1) ,a Sandall sensitivity of (0.024 µg.cm-2) , correlation coefficient of (0.990) , detection limit (0.013 µg.ml-1) and the relative standard deviation of RSD% (1.51-5.35).The developed method was applied to successfully for the estimation of bisacodyl tablets and suppositories.
Keyword: Bisacodyl, Determination, Oxidative Coupling, Ansidine
DOI: https://doi.org/10.31838/ijpr/2019.11.03.050
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