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The protective effect of the N-acetylcysteine on acute liver toxicity induced by carboplatin in rat model
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| Author:
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EKHLAS HASSAN,, SAHAR ABDULRUDHA MAJEED, AMMAR RASOUL MOHAMMAD, KARRAR KAREEM GAEN
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| Abstract:
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Carboplatin is a second generation platinum chemotherapeutic agent. Hepatotoxicity is a major dose regulating-factor
while high dose platinum chemotherapy has been continued. Aim of this study is to test the hepatoprotective effect of
the N-acetylcysteine (NAC) on acute liver toxicity induced by carboplatin in rat model. 24male and female sexually
mature Sprague-Dawley rats were encompassed in this study, randomly divided into 4 groups, each one included 6
rats. group 1 received saline & considered as control group, group 2 received NAC, group 3 received carboplatin &
group 4 received carboplatin + NAC for five days . After treatment, blood samples were collected from animals for
measuring of serum total bilirubin, AST, ALT & LDH then animals were killed & dissected. Liver tissue of rats in all
groups were examined for histopathological changes . carboplatin cause significant elevation in total bilirubin, AST,
ALT & LDH (p< 0.001)with marked histopathological changes in liver suggesting carboplatin- induced hepatotoxicity.
Group of rats treated with carboplatin & NAC had significant reduction in total bilirubin, AST, ALT & LDH (p< 0.001)
with slight histopathological changes in liver suggesting protective effect for NAC against carboplatin- induced
hepatotoxicity. NAC could be had protective effect on carboplatin- induced hepatotoxicity.
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| Keyword:
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carboplatin, liver toxicity, N-acetylcysteine .
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.03.057
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| Download:
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