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Development of Polyherbal Formulation and Immunomodulatory Activity Study
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UPLOADED BY-ADMIN, PANKAJ B. PATEL, BIREN N. SHAH, DIKSHIT C. MODI
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| Abstract:
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The study was carried out to explore the immunomodulatory activity of combined extracts of Nelumbo nucifera (Rhizomes),
Piper nigrum (Fruits), Tinospora cordifolia (Stem) and Asparagus racemosus (Root). The above mentioned plants
have been reported to improve the immune system of the body. So, piece of research work was to observe the combined
effect of all above mentioned plant’s ethanolic extracts as an immunomodulator in the form of polyherbal formulation. Suspensions
of two doses were prepared using 2% gum tragacanth as a suspending agent and encoded as F1 and F2. Both the
suspensions were tested for their stability study for one month and also tested for acute toxicity study. Immunomodulatory
activity was carried out using delayed type hypersensitivity model in mice and macrophage phagocytosis by carbon clearance
test. The formulations did not show any sign of toxicity till the dose of 5000 mg/kg. Data obtained from immunomodulatory
activity study showed that both the formulations are able to recover suppressed immune system but formulation 1 is
more effective in comparison with formulation 2. Various parameters like viscosity, pH etc. performed for stability study,
which showed that both the suspension were found to be stable.
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| Keyword:
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Nelumbo nucifera, Piper nigrum, Tinospora cordifolia, Asparagus racemosus, Immunomodulatory activity.
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