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Distribution of genotype and allele frequencies of polymorphism C634G of VEGF-A gene in patients with diabetic retinopathy
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| Author:
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, YUSUPOV AZAMAT FARKHADOVICH, KARIMOVA MUYASSAR KHAMITOVNA, ABDULLAEVA SAIDA IBRAGIMOVNA, BOBOEV KODIRJON TUKHTABAEVICH
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| Abstract:
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Aim: To study the polymorphism of C634G gene of VEGF-A in patients with nonproliferative diabetic retinopathy.
Material and research methods: The study included 40 patients with type 2 diabetes mellitus (17 men and 23
women), 48 to 70 years old (mean age - 51±2.92 years old), with NPDR, and 50 healthy individuals (mean age -
31.2+0.5 years old). All patients with diabetes mellitus and 50 healthy donors of Uzbek nationality, who made up
the control group, underwent PCR genotyping of polymorphism C634G of VEGF-A gene.
Results: The obtained results on polymorphism of C634G gene of VEGF-A demonstrated a high frequency of
occurrence of the mutant allele G among DR patients in comparison with the control group.
Conclusions: As a result of the study of the polymorphic locus C634G of the VEGF-A gene, pronounced
differences between a group of patients and healthy individuals in the Uzbek population were found. In the
presence of the unfavorable G allele, the risk of diabetic retinopathy development increases by more than 2.1
times.
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| Keyword:
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Nonproliferative diabetic retinopathy, polymorphism, C634G gene VEGF A, mutant allele G.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.03.082
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| Download:
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