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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Cytotoxicity Effecting of New Ligand (LCl) and it's Complexes on a breast cancer

Author: HUDA SAGBANLATEEF, AREEJ ALI JARULLAH, FADHILLAFTAFARAJ
Abstract: In this research, new ligandLCl have been synthesized successfully by the condensation reaction of 2-methoxy aniline with 2-(6-chloro-3,3dimethyl-3H-indol-2- yl)malonaldehyde. The new ligand used to synthesis a series of a new complexes by its reaction with some of transition elements salts such as manganese chloride tetrahydrate, cobalt chloride hexahedrate, nickel chloride hexahedrate, copper chloride dihedrate and zinc chloride.The new ligand and its complexes were characterized by using 1H, 13C NMR, APT 13CNMR, FT-IR, UV-Visible,atomic absorption spectroscopy,elementanalysis C.H.N,magneticsusceptibility and conductivity measurements, as well as some their physical properties were determined like, melting points and colors.The results indicated that all complexes showoctahedralgeometry.The toxicity of the ligand LCl was examined in the MCF7 cancer cell line (breast cancer cell line) with various concentrations (15.1, 31.2, 62.5, 125, 250, 400 and 500 µg/ml) at time of exposure 24 hrs. Where the results showed the concentration of ligand LCl (500µg/ml) registered highest inhibition rate. Add to that the toxicity of LCl complexes were evaluated against the MCF7 cancer cell line after exposure to (500µg/ml) of complexes for 24 hrs., and the results indicated that the inhibition rate for ligand greater than inhibition rate for complexes.
Keyword: 2-methoxy aniline, LCl ligand,breast cancercell line
DOI: https://doi.org/10.31838/ijpr/2019.11.04.001
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