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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and characterization of new 1,2,4-triazole, Oxazoline and Thiazoline derivatives from 2,5 dimarcaptothiadiazole

Author: MOHAMMAD R. AHMED
Abstract: This research includes the synthesis of new heterocyclic containing 1,2,4-triazole, oxazoline and thiazoline derivatives of 2,5 dimarcaptothiadiazole . The preparation process started by the reaction of 2,5 dimercapto 1,3,4 thiadiazole (1) with ethyl chloroacetate to give diethyl 2,2`-(1,3,4-thiadiazole-2,5-diyl)bis(sulfanediyl)diacetate (2). Compound (2) reacted with hydrazine hydrate to give 2,5 bis(mercapto acetichydrazide) 1,3,4 thiadiazole(3). Compound (2) reacted with thiosemicarbazide to give 2,2'-(2,2'-((1,3,4-thiadiazole-2,5-diyl)bis(sulfanediyl))bis(acetyl))bis(hydrazine-1- carbothioamide) (2a). Compound (3) reacted with (phenylisocynate or phenylisothiocynate) to give 2,2`-( 2,2`-((1,3,4- thiadiazole-2,5-diyl)bis(sulfanediyl))bis(N-phenylhydrazine-1-carboxamide) and 2,2`-( 2,2`-((1,3,4-thiadiazole-2,5- diyl)bis(sulfanediyl))bis(N-phenylhydrazine-1-carbothioamide) (4-5). Compounds (2a,4,5) reacted with 4N sodium hydroxide solution to give 1,2,4-triazole (2b,4a,5a). Compounds (4 or 5) reacted with (p-bromophenacyl bromide and p-phenylphenacyl bromide) to give oxazoline (6,7) and thiazoline (8,9) derivatives.
Keyword: triazole, oxazoline, thiazoline
DOI: https://doi.org/10.31838/ijpr/2019.11.04.011
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