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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A one-pot Synthesisof 2,3-Dihydroquinazolin-4(1H)- onesvia Three-Component Cyclocondensation Reactionof Isatoic Anhydride, Amines,andAldehydesCatalyzed by NaHSO4

Author: OBAID ABID, AHMED KHAMEES RAMADAN
Abstract: Number of new derivatives of 2,3-Dihydroquinazolin-4(1H)-ones were synthesized by direct one-potthree component coupling cyclocondensation reaction of isotonic anhydride, amines, and aldehydescatalyzed NaHSO4under refluxing condition in THF in high yield.The structure of the target compounds were investigated by their melting point,FT-IR, and1H-NMR and 13C-NMR of selected derivatives.
Keyword: Quinazoline, Isatoic Anhydride, Amines, Aldehydes.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.014
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