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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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IN-VITRO CHARACTERIZATION AND AEROSOL DISPERSION PERFORMANCE OF TERBUTALINE SULPHATE AND ITRACONAZOLE NANOPARTICLES AS DRY POWDER INSUFFLATION FOR THE TREATMENT OF ASTHMA PREPARED BY PHYSICAL MIXING AND SPRAY DRYING

Author: VENUGOPALAIAH.PENABAKA , B.KUMAR, N.B.L.PRASAD
Abstract: The objective of the present work was to check an Aerosol Dispersion Performance of Terbutaline Sulphate and Itraconazole Nanoparticles as Dry Powder Insufflation for the treatment of Asthma. Dry powder nanoparticles of Terbutaline Sulphate and Itraconazole were aimed to develop using lactose and trehalose as carriers by physical mixing and spray drying. In this work spray dried nanoparticles containing Terbutaline Sulphate, Itraconazole and combination of both was rationally designed via organic solution advanced spray drying (no water) in closed mode from dilute feed concentration. It was observed that Scanning electron microscopy showed smooth and nearly spherical particles for spray dried formulations whereas formulations prepared through milling were found to have rough and irregular in shape. The Mean Median Aerodynamic Diameter (MMAD) values for milled systems decreased when compared to unmilled systems. For all physically mixed systems, the MMAD values ranges from 3.19 µm to 4.78 µm whereas the Geometric Standard Deviation (GSD) values were 1.50–2.96 µm. MMAD values for spray dried formulations ranges from 3.45 µm to 4.21 µm whereas the GSD values were 1.85–2.83 µm. These results concluded that, this novel dry powder inhaler has great potential in treatment of asthma.
Keyword: Terbutaline Sulphate, Itraconazole, Lactose, Trehalose, Physical mixing, Spray drying, Aerosol dispersion performance.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.019
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