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Study of Histological Changes in Rat Embryos Treated with Hot Water Cassia Senna Extract
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| Author:
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NAWRAS HUSSEIN, DR. JABBAR ABADI MOHAMMED
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| Abstract:
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The study was performed at the animal house of Biology department, College of Education for girls and
included the use of 16 laboratory rat animals of Sprague-Dawley strain,12 female and 4 males (for vaccination
only) randomly divided into four equal groups: the first group was administrated with distilled water (negative
control),the second group was orally administrated with aqueous extract of Cassia senna leaves 100mg/kg/day,
the third group was orally administrated with aqueous extract of Cassia senna leaves 150mg/kg/day, the fourth
group was orally administrated with aqueous extract of Cassia senna leaves 250mg/kg/day. The treatment of all
groups (experimental animals) was once daily (1- 20 day of pregnancy).The histological examination of embryo
livers that treated with plant extract100mg/kg/day pointed to obtain haemorrhage. As for 150mg/kg/day
pointed to obtain dilation of the sinuses, the appearance of cells of the Thame, increase the size of the nucleus
to the cytoplasm, nuclei fragmentation and increase haemorrhage. In 250mg/kg/day pointed to obtain
haemorrhage, the appearance of cells of the Thame, congestion of central vein, dilation of sinusoid and
vacuolization. We conclude from the present study that the aqueous extract of Cassia senna is not safe for
consumption and has negative effects so we recommend to avoid its use, especially on pregnant women.
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| Keyword:
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Cassia Senna, Cytoplasm, Haemorrhage.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.04.076
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| Download:
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