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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Assessment of anti-quorum sensing potential of selected medicinal plant extracts using Chromobacterium violaceum

Author: GUNJANKUMAR MEHTA, VASANTBA J. JADEJA
Abstract: Quorum sensing is recognized as potential target for developing new antimicrobial agents. In present study, antiquorum potential of plant extracts was investigated using wild type bioreporter bacterial strain Chromobacterium violaceum MCC 2290 (ATCC® 12472™). It produces Violacein (violet colour) pigment in a quorum sensing dependent manner. Chromobacterium violaceum CV026 MCC 2216, a Violacein negative mutant was used to determine mode of action of crude extracts. Out of total 25 plants screened, the anti-quorum sensing properties were found in crude extracts of Punica granatum L., Terminalia bellirica Roxb. and Terminalia chebula Retz. with varying degree of effect. Most potent anti- quorum sensing activity was found in Punica granatum L. with 41.92 % Violacein inhibiton. All the extracts were found effective at low concentration = 0.075 mg/ml. The presence of anti-quorum sensing phytoconstituents and their chemical nature were analysed by thin layer chromatography which indicated them to be polar. The inhibitory effect of plant extract on Violacein production was assessed by qualitative and quantitative methods.
Keyword: Quorum sensing inhibition, Chromobacterium, Phytomedicine, Antibiotic resistance
DOI: https://doi.org/10.31838/ijpr/2019.11.04.038
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