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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Immunity of the Nasal Mucosa in Premature Infants of the First Year of Life

Author: ALBINA KALIMULLINA, VICTORIA AMIROVA, LILIYA AZNABAEVA, SVETLANA LARIONOVA, NATALIA SHAFAZHINSKAYA, NIKITA LOGACHEV, NIKOLAI MAKSIMYUK
Abstract: The indices of immunity on the nasal mucosa were studied in 47 children of the first year of life born prematurely at the gestational age of 28-37 weeks. ELISA test was used to determine antibodies (IgA, IgG, IgE) and cytokines (TNF-a, IL-1ß, IF-?) of nasal mucosa washes. The study found that premature infants had transient deficiency of IgG at the age of 6 months (2.08 (0.78-6.99) mg/ml) and low IgE indices at the age of 12 months (0.89 (0.47-of 1.32) ng/ml) against hyperproduction of IL-1ß and low idices of IF-? at the age of 6 months (7.51 (4.84-13.82) pg/ml) and 12 months (8.28 (4.70-12.07) pg/ml). Infants born at the gestational age of 28-32 weeks had the worst antibody and antiviral protection. The findings may be useful in the development of measures for the prevention and treatment of inflammatory respiratory infections in premature infants.
Keyword: immunity of the nasal mucosa, nasal cavity, premature infants
DOI: https://doi.org/10.31838/ijpr/2019.11.04.115
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