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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of the Effect of Caffeine on Apnea of Preterm Neonates Hospitalized in Intensive care unit: A clinical trial

Author: ALIREZA MOTLAGH, PARASTO TOSI, MITRA RAHIMZADEH
Abstract: Introduction: Respiratory disorders are one of the most important problems seen in preterm neonates and the treatment or prevention of these disorders is crucial to improve the condition of the neonates. The objective of this study was to evaluate the effect of caffeine on the prevention of apnea in neonates hospitalized in Bahonar and Kamali hospitals in Karaj. Methodology: In this double-blinded randomized clinical trial, 48 neonates hospitalized in Bahonar and Kamali hospitals of Karaj in 2017-2018 were randomly assigned to one of two groups of intervention and control using the randomized numbers table. The intervention group received 20 mg/kg intravenous caffeine as the initial dose on the first day and 5 mg / kg intravenous caffeine daily as the maintenance dose for the first 7 days of life and the control group received normal saline at equal volume (approximately 3 cc) for the first 7 days of life. Then, treatment outcomes including bradycardia, cyanosis and apnea were compared in two groups. Results: The results revealed no statistically significant difference between the two groups in terms of treatment indicators, including bradycardia, cyanosis and apnea (P> 0.05) and no significant difference was found between the two groups in terms of reduction in oxygen saturation. Moreover, the level of tachycardia and dependency on oxygen was not significantly different in two groups. Conclusion: Apnea is a common problem in preterm and low birth weight neonates. The results of this study revealed that caffeine had no significant impact on the prevention of apnea in preterm neonates, but it had an effect on reducing oxygen saturation. Thus, further studies with larger sample size are recommended in this regard and more studies are recommended to compare the preventive and therapeutic effects of caffeine on apnea and other complications of preterm neonates.
Keyword: Caffeine, Apnea, Preterm neonate
DOI: https://doi.org/10.31838/ijpr/2019.11.04.117
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