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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Diabetic Nephropathy: A Review of Pathophysiological mechanisms, Therapeutic interventions and Biomarkers

Author: REEMA MITRA, , PRADEEP GOYAL
Abstract: Among the three microvascular complications of diabetes (nephropathy, retinopathy and neuropathy), diabetic nephropathy is a major cause of kidney failures. This review gives an insight into all the pathways and mechanisms which have been implicated in causing kidney damage due to diabetes. Both metabolic and haemodynamic factors play a role in the disease. Various mechanisms like activation of protein kinase C, polyol pathway, etc lead to nephropathy. The review also summarises some of the newer therapeutic options for the treatment of the disease
Keyword: Diabetic nephropathy, pathophysiological mechanisms, therapeutic options
DOI: https://doi.org/10.31838/ijpr/2019.11.04.201
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