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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and characterization of some new Pyrazolin, Triazolin and Tetrazolin derivatives of 1,8-naphthal imide and evaluate their anti-microbial activity

Author: MOHAMMED AL-KHUZAIE, SUAAD M.H. AL-MAJIDI
Abstract: New pyrazolin, triazolin and tetrazolin derivatives of 1,8-naphthalimide had been synthesized from 1, 8naphthalic anhydride by reaction with p-phenylenediamine to give 1,8-naphthalimide derivative [1], that converted into its diazonium salt derivative by using sodium nitrite and acetic acid. Then, the diazonium salt reacted at the first time with acetylacetone to give compound [2] that react with hydrazine derivative to produce pyrazolin derivatives [3-7]. At the second time, diazonium salt reacted with sodium azide to produce azide derivative [8] that react with unsaturated carbonyl compounds to obtained 1,2,3-triazolin derivatives [913]. Also, azide derivative [8] react with some of Schiff’s bases derivatives [14-18] of compound [1] to produce tetrazolin derivatives [19-23]. The New pyrazolin, triazolin, and tetrazolin derivatives had been identified by [ C-NMR, and FTIR] and by measuring of characteristic physical properties and specific reactions. Moreover, the biological effect of all prepared compounds was tested on fungicidal and some of the bacteria.
Keyword: 1,8-naphthalic anhydride, triazolin, tetrazolin, pyrazolin, anti-microbial activity.
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