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Synthesis and characterization of some new Pyrazolin, Triazolin and Tetrazolin derivatives of 1,8-naphthal imide and evaluate their anti-microbial activity
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| Author:
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MOHAMMED AL-KHUZAIE, SUAAD M.H. AL-MAJIDI
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| Abstract:
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New pyrazolin, triazolin and tetrazolin derivatives of 1,8-naphthalimide had been synthesized from 1, 8naphthalic
anhydride by reaction with p-phenylenediamine to give 1,8-naphthalimide derivative [1], that
converted into its diazonium salt derivative by using sodium nitrite and acetic acid. Then, the diazonium salt
reacted at the first time with acetylacetone to give compound [2] that react with hydrazine derivative to
produce pyrazolin derivatives [3-7]. At the second time, diazonium salt reacted with sodium azide to produce
azide derivative [8] that react with unsaturated carbonyl compounds to obtained 1,2,3-triazolin derivatives [913].
Also,
azide
derivative
[8]
react
with
some
of
Schiff’s
bases
derivatives
[14-18]
of
compound
[1]
to
produce
tetrazolin
derivatives
[19-23].
The
New
pyrazolin,
triazolin,
and
tetrazolin
derivatives
had
been
identified
by
[
C-NMR, and FTIR]
and by measuring of characteristic physical properties and specific reactions. Moreover, the biological effect of
all prepared compounds was tested on fungicidal and some of the bacteria.
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| Keyword:
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1,8-naphthalic anhydride, triazolin, tetrazolin, pyrazolin, anti-microbial activity.
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| EOI:
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-
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| DOI:
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