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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Ginsenoside in Induced Renal IschemiaReperfusion Injury in Mice

Author: YASMEEN HUSSIEN, HUSSEIN ABDALKADIM, NAJAH R. HADI, WADDAH MAHBOBA, HAYDER A. AL-AUBAIDY
Abstract: Ischemia-reperfusion injury (IRI) is a common injury of multiple organs including kidney, heart, and brain. It is expected injury that can occur after myocardial infarction, sepsis, organ transplantation, which characterized by restriction of blood supply to an organ followed by restoration of blood flow and re-oxygenation. Acute kidney injury (AKI) is a common clinical pathology characterized by rapid deterioration of renal function.AKI is the most common causes is ischemia/reperfusion (I/R) injury, Which can be classified according to the etiology into the major categories: prerenal, intrarenal, and postrenal. In hospitalized patients. Prerenal cause of AKI accounts for 25% and intrarenal cause account for 35–70% of AKI cases. Postrenal cause generally accounts for <5% of AKI. This study aimed to investigate the possible protective effect of Ginsenoside by determining renal biomarkers on experimentally induced ischemia-reperfusion injury in mice.
Keyword: Renal Ischemia /Reperfusion, Ginsenoside
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