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The therapeutic effect of the active compound derived from green tea on induced infection of Entamoebahistolytica in mice
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| Author:
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SURA ABDULATEEF, HASANA. AAL OWAIF , MANHAL F. AHMED
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| Abstract:
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Entamoebahistolytica is the causative parasite of amoebiasisthat mainly occurring in tropical regions. The present study
showed the therapeutic effect of the caffeine extracted from the green tea on the laboratory mice that experimentally
infected by E. histolytica. A total of 52 samples of stool were collected from the Child’s Central Teaching Hospital and
Al-Yarmouk Teaching Hospital in Baghdad city, and then E. histolytica was isolated and identified. The extraction of
caffeine was confirmed by HighPerformance Liquid Chromatography
(HPLC
) and its purity was identified comparing to
the standard caffeine. The results showed the effect of three different concentrations
(2.5, 5, 10 mg/ kg
)of caffeine on
the histomorphological changes in the cecum tissue of the E. histolytica-infected mice. After treatment with these
concentrations, the infected cecumtissue was either recovered to the normal histomorphological conditionor got an
increase in the underlying cells number, an increase in the mucin secretion and few leaching of inflammatory cells.
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| Keyword:
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Entamoebahistolytica, Green tea, Cecum
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.042
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| Download:
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