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Preparation, spectral characterization and biological activity of somenewbimetalic complexes derived from{ 2,2`( (5-methyl-1,3-phenylene )-bis- (oxy ) )-bis-N`(E`)-2- hydroxybenzylideneacetohydrazide}ligand
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| Author:
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MAHA MUSTAFA, RIYADH M. AHMED
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| Abstract:
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In this work, the preparation of new multidentate Schiff-base lig and and its metal complexes are described. The
formation
of
the
lig
and{
2,2`
(
(5-methyl-1,3-phenylene
)-bis-
(oxy
)
)-bis-N`
(E`
)-2-
hydroxybenzylideneacetohydrazide}[H2L] was prepared from the reaction {2,2-
(
(5-methyl-1,3-phenylene
)-bis-
(oxy
)
)-
di-
(acetohydrazide
)}[M]precursor and salicylaldehyde in a 1:2 mole ratio, respectively. The reaction of the lig and
[H2L] with
+3
(Cr
, Mn
+2
and Fe
+2
)metal ions in a 1:2
(L:M
) mole ratio. Ligand and complexes were characterised via
spectroscopic analyses; [FT-IR, UV-Vis spectroscopy,
(C.H.N
) microanalysis, chloride content, thermal analysis(TG
),
electrospray mass, magnetic susceptibility and conductivity measurements. The characterisation data showed the six
coordinate complexes with the general formula;[M2
(L
)Cl4]
(where M= Cr
+3
)and K2[M2
(L
)Cl4]
(where M= Mn
+2
and
+2
Fe
).The ligand [H2L] and its complexes were screened for their antimicrobial activity against four bacterial species
(Bacillus subtitles and Staphylococcus aureus) G-positive ,
(Escherichia coli and Pseudomonas aeruginosa
) G-negative
and two fungi species(Candida and trichomoniasis). Biological data indicated that complexes become potentially
more active against several type of organism, under survey compared with the free lig and.
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| Keyword:
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multidentate Schiff-base ligand; benzylideneacetohydrazide; spectroscopic analyses;Biological activity.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.046
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| Download:
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