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Microemulsion -based hydrogel formulation Promotes the Dermal Delivery of Aceclofenac
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| Author:
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DHIREN SHAH*, KOMAL PATEL
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| Abstract:
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The intent of research work was to improve the solubility of Aceclofenac and to enhanced retention of Aceclofenac
on the skin by formation of microemulsion based hydrogel. Preliminary batches were selected according to pseudo
ternary phase diagram and concentrations of all exicipients were selected out. Aceclofenac microemulsion
formulations were characterized by % Transmission, pH, viscosity, conductivity, drug content, droplet size & zeta
potential measurement and In-vitro permeation study. Aceclofenac microemulsion F9 containing surfactant: co- surfactant & water: oil ratio i.e. 5:3 & 1:3 was considered as optimized batch based on % transmission (98.9%), %
cumulative drug release and droplet size (30.71nm). Optimized Aceclofenac microemulsion formulation was
incorporated into hydrogel containing 1.5% w/w carbopol P934 to improve viscosity of formulation for topical delivery
system. Aceclofenac microemulsion based hydrogel formulation was characterized by various parameters like pH,
viscosity, spreadability, % drug content, comparative in-vitro and ex-vivo permeation study and skin irritation.
Aceclofenac microemulsion based hydrogel formulation has good spreadability and viscosity to retain and no skin
irritation after 48 hr. Aceclofenac microemulsion based hydrogel formulation shown the controlled released pattern of
Aceclofenac with topical formulation.
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| Keyword:
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Aceclofenac; Microemulsion, Hydrogel, Droplet size analysis; Ex-vivo skin irritation.
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| EOI:
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| DOI:
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| Download:
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