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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and biological evaluation of Schiff bases and pyrazole derivatives derive from chalcones, (2E)1-(4-aminophenyl)-3-(2-furyl)prop-2-en-1-one

Author: ALI HASSAN, HAMID H. MOHAMMED
Abstract: This work describes the synthesis of Schiff bases (2-8), pyrazoles and (9-18) derivatives from chalcones (1), (2E)-1-(4-aminophenyl)-3-(2-furyl)prop-2-en-1-one, and some biological studies of these compounds against (gram +ve) bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and (gram –ve) bacteria (Escherichia coli and Klebsiellapneumniae); and antifungal actioncontra (Candida albicans) .Series of biologically active substituted Schiff bases(2-8) were synthesized from chalcone (1) and different substituted aldehyde compounds in the presence of piperidine as catalysis and ethanol as a solvent.Some of Schiff bases compounds on reaction with phenylhydrazine or hydrazinehydrate in ethanol as a solvent give pyrazole derivative (9-18). The homogeneity of all the newly synthesized compounds has been checked by TLC. The chemical structures of the newly synthesized compounds were confirmed by FTIR, HNMR spectroscopic analysis, and the data are in accord with the assigned structure.
Keyword: chalcone, Chiff bases, pyrazole, biological evaluation
DOI: https://doi.org/10.31838/ijpr/2020.12.01.138
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