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Chronic Toxicity Evaluation of Ayurvedic Arsenical Formulation Rasamanikya with Special Reference to Heavy Metal Toxicity.
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| Author:
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NILIMA WADNERWAR, ABHAY PATKAR
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| Abstract:
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Background: On the ground where formulations of Ayurved are targeted to contain high levels of heavy metals, the attempt has been made to evaluate the toxicity of an Ayurvedic formulation containing Arsenic as one of the heavy metals. Rasamanikya is an arsenical formulation made up of Haratala (Arsenic trisulphide) and it is very popular for its therapeutic utility in skin and blood disorder. Due to the concern of heavy metal toxicity, the question raised about the safety of the formulations of Ayurved containing heavy metals.
Objectives: This research topic was selected for detail study of chronic arsenic poisoning supposed to occur from the long term use of Rasamanikya under heavy metal toxicity with the help of animal model.
Material and methods: Arsenic content was estimated in Rasamanikya sample procured from the market and study was conducted to estimate its LD50 which was followed by chronic toxicity study in Wistar rats. Hematological and biochemical parameters were assessed at 30, 60 and 90 days and histopathological study was conducted at the end of the study.
Result: There were no significant differences observed most of hematological and biochemical parameters up to 60 days in Wistar rats. No significant differences in body weight and relative organ weight were observed. Minimal to mild changes were observed in liver and kidney which were pathologically insignificant.
Conclusion: LD 50 of Rasamanikya may be more than 2000 mg/kg and Rasamanikya is safe for 15 days duration in the therapeutic dose in human beings. Chronic Arsenic toxicity due to Rasamanikya is not possible if it is consumed in therapeutic dose for 10- 15 days.
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| Keyword:
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Heavy metal; Chronic Arsenic toxicity; Rasamanikya; LD50; Haratala; Heavy metal toxicity
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.004
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| Download:
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