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Formulation and Characterization of Diclofenac Diethylamine Loaded Microsponge Based Gel for Sustained Drug Delivery
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| Author:
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NARESH KSHIRASAGAR, GOVERDHAN PUCHCHAKAYALA, BALAMURUGAN.K
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| Abstract:
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The new investigation behind the present work was to envisage microsponges based novel drug delivery system for sustained action of Diclofenac Diethylamine(DDEA) microsponges through Quai-emulsion solvent diffusion method which was engaged using Ethyl cellulose (EC), Eudragit RS100 (ERS) and Poly Vinyl Alcohol (PVA) as carriers with various drug-polymer ratios for the preparation of microsponges. For optimization purposes, several factors are considered in investigation. Characterization techniques followed for the formed microsponges were Fourier Transformer Infrared (FTIR), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), particle size analysis, along with morphology, drug loading, in vitro and ex vivo drug release. It was found that there is no interaction between the drug-excipients as per DSC and FTIR results. The drug polymer ratio showed great impact on encapsulation efficiency, particle size and drug content. SEM studies showed that morphological microsponges are spherical and porous in nature and with mean particle size of 33 µm. The microsponges were then loaded in gel followed by in vitro drug release studies by modified Franz diffusion cell, in vitro drug release results depicted that microsponges with ethyl cellulose 1:2 drug-polymer ratio were more effective to give extended drug release 76.49±0.261% at the end of 8hrs, which conventional formulation get exhausted earlier by releasing 96.99% drug release at the end of 5 hrs, only topical application of optimized microspongial gel enhanced drug residence time in the skin and therapeutic concentration is maintained for extended period of time, which is possible to show sustained action of drug.
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| Keyword:
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Microsponges; Franz diffusion cell; Diclofenac Diethylamine; Sustained action; Flux; Permeability coefficient.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.0004
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| Download:
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