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In-Vivo Shielding Effects of Semecarpus anacardium Extract in Presenile Dementia.
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| Author:
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SAXENA GAURAV, SINGH HANSRAJ, KUMAR NITIN, SELIYA MAMTA, KUMARI NUTAN
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| Abstract:
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Background: Dementia is a common symptom of Alzheimer’s Syndrome. Aluminium, a standard neurotoxin, is
hypothesised as one of the contributory factors of AD. Ballantaka (Semicarpus anacardium) is traditionally used in
Ayurvedic formulary for management of several ailments. The drug is already recognised as counter-inflammatory,
anti-microbial and anti-oxidant therapeutic agent. The investigation aimed analysis of the wholesome influence of
extract of S. anacardium nut (SANE) on aluminium-induced cognitive decline of the central nervous system of
rodents.
Methods: S. anacardium nut extract was standardised using a Butein (3,4,2',4'-tetrahydroxychalone), as the marker
compound. The Wistar male albino rats (200 to 250 gm) were randomly allocated into three groups (n = 6).
Rodents were initially given S. anacardium nut extract, and AlCl3 was later used to induce dementia. At the end of
the study, metabolic and pathological changes were observed.
Results: Rodents given with SANE showed a notable decline in the level of cholinesterase and amyloid plaque
accumulation in the brain, especially in comparison to the AD group. There has also been a decline in ELT (Escape
Latency Time) and an increase in memory of rodents fed Semecarpus anacardium extract (SANE) concerning
Alzheimer's disease group.
Conclusions: The study revealed that S. anacardium extract ameliorates aluminium triggered deviations in
behavioural besides lucidity function, oxidative stress and cephalitis. This plant could thus use this as an adjuvant in
anti-AD preparation.
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| Keyword:
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Alzheimer's, ROS, AchE inhibitory activity, Amyloid plaque, Morris watermaze, Semecarpus anacardium
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.164
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| Download:
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