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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Microsatellite instability in uterine cancer

Author: ALAA ALAM, HAWRAA SAHIB ABID , NAJAH R. HADI
Abstract: Background: Microsatellite instability is present in high proportion of endometrial carcinoma (15-20%). Failure to correct slipped-strand misparing occur during replication of DNA due to defect in mismatched repair system. This will cause microsatellite instability. This meta-analysis was designed to predict a more precise estimate about the proportion of endometrial carcinoma harboring microsatellite instability. Electronic data bases were thoroughly searched for to pick up eligible articles in respect to sample size, studies population and the presence of microsatellite instability. Out of 16 studies having 5872 cases of endometrial cancer, the pooled proportion of MSI endometrial carcinoma was shown to be about 22.816 % (95% CI and 17.943 to 28.087), there was an obvious significant heterogeneity between them (p < 0.0001). In short, the frequency of the MSI phenotype in endometrial carcinoma cancers approximates 22.816%. Paying attention to the possibility of the presence of microsatellite instability may enhance clinical implication in future management of the tumor.
Keyword: MSI: microsatellite instability, MMR-D: mismatched repair gene deficiency, EC: endometrial carcinoma.
DOI: https://doi.org/10.31838/ijpr/2020.12.01.179
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