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Detection of biomarkers in serum and synovial fluid of Iraqi patients with knee osteoarthritis
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| Author:
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MOHAMMED ABOOD, MAYSAA ALI ABDUL KHALEQ, ABATHAR A. SADIQ, NAJAH HADI
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| Abstract:
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Osteoarthritis is believed to be the most predominant incessant joints ailment. The rate of osteoarthritis occurrences is raising a direct result of the maturing populace; it is moreover associated with a combination of both modifiable and non-modifiable hazard factors encompasses; absence of activity, weight gain, occupational injury , bone thickness, hereditary inclination, trauma, and gender. Clinical highlights that lead to treatment are agony and loss of capacity, involving life style modification, medical treatment, and surgical methodologies. The determination of osteoarthritis by clinicians is developed late in the disease process, perhaps past the point where it is possible to expect a lot of help from disease-modifying drugs. In spite of endeavors over the previous decades to create biomarkers for osteoarthritis, as yet image studies and biochemical markers examinations should be enhanced and perhaps stretched out with increasingly explicit and delicate strategies to dependably depict illness forms to analyze the ailment at a beginning period, to categorize sufferers as indicated by their anticipation, to pursue the course of ailment and therapy. In future, superior meaning of the diseases expected by outlining various phenotypes of the sickness, therapy focused more specifically at these phenotypes may prompt enhanced results.
Objective: The main objective of the present paper is the early diagnosis of osteoarthritis by detection of biomarkers in serum and synovial fluid in Iraqi patients suffering from knee osteoarthritis.
Patients and Methods: This study involves 100 participants; 50patients suffer from knee osteoarthritis and 50 healthy controls. Platelets numbers (PLT), level of erythrocyte sedimentation rate (ESR), level of C - reactive protein (CRP) and level of C3 complement were collected and studied.
Results: A significant increase in the level of biomarkers; platelet number (PLT), erythrocyte sedimentation rate (ESR), C - reactive protein (CRP) and C3 complement were demonstrated in patients with osteoarthritis compared to healthy individual. These increments demonstrate a noteworthy positive relationship between the state of patient and the severity of the disease.
Conclusion: These results provide an evidence for the significant role of biomarkers in the determination of the early stages of the disease and thus obtaining better results and improving the quality of life of the patient.
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| Keyword:
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knee osteoarthritis, synovial fluid, PLT, ESR, CRP, C3 complement
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.01.182
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| Download:
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