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Antiradical activity of new synthetic substituted 8,8-dimethyl-3,7,8,9-tetrahydro-2?-pyrido[4,3,2-de]cinnolin-3-ones
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| Author:
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ZYKOVA S.S, SHUROV S.N, TALISMANOV V.S, KARMANOVA O.G
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| Abstract:
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The target 5-aryl-2-benzyl-8,8-dimethyl-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]cinnolin-3-ones and 2,5-diaryl-8,8-dimethyl-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]cinnolin-3-ones were derived by cyclization of substituted 2-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydroquinoline-4-carboxylic acids with arylhydrazines and benzylhydrazines.The highest antiradical activity is shown by the target compounds containing the p-tolyl, p-bromine, p-chlorophenyl and 2-naphthyl substituents and the lowest is shown by the p-fluorophenyl substituent.
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| Keyword:
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antiradical activity, arylhydrazines, benzylhydrazines, cynnolin-3-ones
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.0068
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| Download:
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Request For Article
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