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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Treatment of Severe Forms of Lichen Ruber Planus Of Oral Mucosa using Photopheresis of Topical Steroids

Author: OLGA SERIKOVA, NIKOLAY P. SERIKOV, ELENA V. SURZHENKO, ARMAN A. OGANESYAN, SERGEY N. GONTAREV, ALEXANDER S. RAPUTA
Abstract: Aim: The purpose of the research is to search for new techniques of surgery for lichen ruber planus with high efficacy, few complications, and side effects, as well as providing a long-term therapeutic effect. Materials and method: During 2012-2017, the authors used the technique of photophoresis (red LED radiation + topical steroid) taking of 40 patients with severe forms of lichen ruber planu as the case of the study. they studied in 2 groups of a control group (19 patients) and basic (20 people), depending on the methods of treatment. Results: This article is dedicated to the effects of the treatment of severe forms of lichen ruber planus of the oral cavity: erosive-ulcerative and exudative-hyperemic, based on the use of photophoresis in combination therapy. The Russian Device Activator LED-Active 5, produced by the Voronezh company Medtorg+ LLC, was used as a source of red LED radiation. Conclusion: Thus, the conducted research suggests that the use of photophoresis of topical steroids in the combination treatment of severe forms of lichen ruber planus of the oral mucosa allows to shorten the terms for the elimination of the inflammatory reaction of the oral mucosa and the timing of epithelization of erosive and ulcerative elements, which increases the efficiency of treatment and the possibility of reducing the dose of corticosteroids.
Keyword: Oral lichen ruber planus, erosive-ulcerative form, exudative-hyperemic form, photophoresis, activator.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.0308
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