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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Study of Elementosis in Obstetrics uncovering the new approaches

Author: TATYANA PAVLOVA, NATALIA B. PILKEVICH, VASILIY A. PETRUKHIN, ?LENA S. MALYUTINA, ARKADY V. NESTEROV, VERA A. MARKOVSKAYA, ANTON N. KAPLIN, LYUDMILA O. ZEMLIANSKAIA
Abstract: Objective: to study macro- and micronutrients in the tissues of the placenta, umbilical cord, and uterus, as well as the erythrocytes of the mother-placenta-fetus system during pregnancy against the background of thyroid gland (TG) pathology of various origins, diabetes I, and gestational diabetes mellitus (DM) (diabetes mellitus DM). Methods: the study used clinical material from 184 pregnant women, 154 of them are women with thyroid disease and 30 are a control group. The thyroid gland (TG) was studied using the Alokka-5500 ultrasound apparatus, as well as triiodothyronine and total thyroxin, free thyroxine, thyroid hormone, and thyroglobulin antibodies were determined. Elemental analysis of oxygen, carbon, phosphorus, calcium, magnesium, iron, nitrogen, aluminum, sodium, and sulfur was carried out using an X-ray spectrum detector (EPAX), integrated with Quanta 600 FEG scanning electron microscope. Results: The study of the main vital elements in the erythrocytes of the umbilical arteries found that significant changes in the macroelement composition are due to oxygen. Its content in group 1 was 30.41±2.10%, in group 2 - 30.71±1.34%, group 3 - 35.92±2.31%, group 4 - 30.92±2.31%, group 5 - 32.93±2.20% (43.92±2.15% - control group). The content of sodium, potassium in the groups with hypothyroidism, diffuse toxic goiter (DTG) and DM I increased. The content of magnesium, phosphorus in the umbilical arteries decreased in the following order: euthyroidism, gestational diabetes, hypothyroidism, diabetes mellitus, DTG. The oxygen content in umbilical veins decreased greater than in the arteries. The amount of sodium and calcium increased with a further decrease in magnesium, phosphorus, and potassium. The macro-and microelement analysis near the vascular wall of the umbilical cord in the pathology of the mother’s thyroid gland found that the content of oxygen, magnesium, phosphorus, and calcium is significantly reduced in endocrinopathies. Summary: as a result of the study, it was established that women with the diseases of the thyroid gland and diabetes have uteroplacental ischemia observed against the background of tissue-vascular lesions, changes in the anatomical and functional states of erythrocytes, macro- and microelement composition, resulting in the developing destruction of tissue in the mother-placenta-fetus system, which contributes to the further progression of tissue and circulatory hypoxia.
Keyword: pregnancy, trace elements, thyroid gland, diabetes mellitus.
DOI: https://doi.org/10.31838/ijpr/2019.11.04.0322
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