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Comparison of Efficacy and Tolerability of Cinnarizine with Betahistine in the Treatment of Otogenic Vertigo
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Author:
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Uploaded By-Admin, Raviteja Bodla, Prasad Thota, Ajaykumar Sarabu, Mohantha GP, Ruta hanmugam
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Abstract:
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Peripheral vestibular disorders frequently lead to the manifestation of symptoms of vertigo. The objective of this study
was to compare the efficacy and tolerability of Cinnarizine 25mg with Betahistine 16mg in the treatment of otogenic vertigo.
Eighty patients with vertigo due to otogenic origin participated in this prospective, comparative, single-centre study. Patients
were randomly allocated to treatment with Betahistine 16mg or Cinnarizine 25mg, given three times daily for 4 weeks. Efficacy
was determined by assessments of vertigo symptoms after 1 and 4 weeks of treatment using a visual analogue scale to
determine 'mean vertigo score'. Treatment with Betahistine led to significantly greater improvements in mean vertigo scores
compared with Cinnarizine. This was evident as early as 1 week after the onset of treatment (p = 0.002). After 4 weeks, Betahistine
decreased the intensity of vertigo symptoms about 2-fold compared with Cinnarizine (p = 0.001). Reductions in
symptoms typically associated with vertigo were more pronounced (p = 0.009) in Betahistine group compared with Cinnarizine
group after 4 weeks of treatment. No serious adverse events were reported in either treatment group. Tolerability of the
Betahistine was judged as 'very good' by 90% (Cinnarizine 97%) and as 'good' by 10% (Cinnarizine 3%). Betahistine was
shown to be effective and very well tolerated treatment option for patients with otogenic vertigo. It proved to be statistically
more efficient in reducing vertigo than Cinnarizine. Therefore, Betahistine may be considered first-line treatment option for
the treatment of otogenic vertigo.
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Keyword:
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Otogenic vertigo, vestibular disorders, cinnarizine, betahistine
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