Impact Factor for Five Years is 1.55 (2012 - 2016). IJPRT Re-launched from 2017, for more details visit www.ijprtonline.com

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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Analytical Method Development and Validation for the Simultaneous Estimation of Ambroxol Hydrochloride and Guaiphenesin in Syrup Dosage form by RP-HPLC
Role of NMDA receptor antagonist in ethanol withdrawal syndrome
STABILITY INDICATING LC-MS/MS METHOD FOR QUANTIFICATION OF IBRUTINIB IN HUMAN PLASMA
A review on drug: Amantadine
Chemopreventive and antioxidative activity of Carissa carandas extract against chemical induced skin tumorigenesis in mice
ROLE OF AMIODARONE IN ACUTE MYOCARDIAL INFARACTION INDUCED VENTRICULAR TACHYCARDIA IN PATIENTS WITH LEFT ANTERIOR DESCENDING ARTERY INVOLVEMENT
Extraction optimisation, fractionation, standardisation, in vitro antioxidant and anticholinesterase activity of fractions of Indian Propolis
Development of validated stability-indicating analytical method for simultaneous estimation of Atenolol and Hydrochlorothiazide in pharmaceutical combined dosage form by High Performance Thin Layer Chromatography.
Lung Cancer in Lifelong Never Smokers-Short Review
3D-Quantitative Structure Activity Relationship Study of Pyrazolothiazol-4-(5H)-One Derivatives as Epidermal Growth Factor Receptor Inhibitors
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IJPRT ISSUE

January - March 6 [1] 2014

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Development and Evaluation of Mucoadhesive Microspheres of an Anti-Diabetic Drug with Natural Polymer

Author: UPLOADED BY-ADMIN, NISHANTH KUMAR N, RAMAKRISHNA RAPARLA, SANTHOSH KUMAR M
Abstract: Gliclazide is an oral hypoglycemic agent used in the treatment of non-insulin dependent diabetes mellitus. Among the people who are suffering from long term disorders, the major had been categorized under the people who are suffering from diabetes and a dosage form is needed for them that should provide continuous therapy and should have a high margin of safety. Microencapsulation plays a great role in providing such a kind of dosage form. Gliclazide microspheres with a coat consisting of alginate and xanthan gum were prepared by orifice-ionic gelation method and emulsification gelation technique. The prepared gliclazide microspheres were evaluated for surface morphology and particle shape, Carr’s index, microencapsulation efficiency, drug release characteristics, compatibility studies rheological studies. The microspheres were found discrete, more spherical and free flowing with emulsion ionic gelation technique. The microsphere size was found in the range 498±12-598±10µm. Sharp endothermic peaks were found from the microspheres formulated with polymers indicating the compatibility between the drug and the polymer xanthan gum. The encapsulation efficiency was found around 57.50±0.59%-61.68±0.43% and percentage drug content is in the range of 19.96±0.48% - 30.09±0.65%. Drug release from the microspheres was found slow, followed zero order release kinetics with non-fickian release mechanism stating release depended on the coat: core ratio and the method employed in the preparation of microspheres. Among two techniques emulsification gelation technique was found to be more suitable for slow and complete release over a long period. These microspheres showed good mucoadhesive property in the in vitro wash of test.
Keyword: Gliclazide, xanthan gum, orifice ionic gelation technique, emulsification ionic gelation technique.
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Chemical Abstract Services
Scopus (Elsevier) (Re-Application is Under Process)
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Ulrich's International Periodical Dictionary
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News & Events
Impact Factor for five years is 1.55 (2012 - 2016)
Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477
Impact Factor for five years is 1.3 (2010 - 2014)