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In Vitro Bioequivalence Study of Formulated Atenolol Tablet with Marketed Brands
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| Author:
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UPLOADED BY-ADMIN, ANURADHA PATEL, JIGNA ROHIT, PARIXIT PRAJAPATI, RIKISHA BOGHRA, ANIL G JADHAV
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| Abstract:
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The aim of the present study was to predict the bioequivalence of formulated Atenolol tablet with marketed brands
using in vitro tests. The in vitro dissolution study was carried out on the formulated of Atenolol tablet and marketed brands
using the paddle method in 0.1 N HCL. Other general quality assessment tests like hardness and disintegration time were
also determined. All the tested parameters were passed the Indian Pharmacopoeia standards (hardness, disintegration time).
To find significant differences in the dissolution profiles of the formulated tablet and marketed brands calculation of
similarity factor was performed. The formulated tablet, and marketed brands STD1, STD2 however, released >90% of
Atenolol within 45 min. The formulated tablet and marketed brand (innovator brand) have calculated for similarity factors by
considering the innovator brand STD1 as 100.Based on the in vitro tests, formulated tablet was considered bioequivalent and
interchangeable with the innovator brand (STD1).
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| Keyword:
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Atenolol Tablets, Bioequivalence, Pharmaceutical Tablet Evaluation Tests, In Vitro Dissolution
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