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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Aqueous Leaf Extract of Samanea saman (Jacq.) Merr. Against Carbon Tetrachloride Induced Oxidative Stress in Rats

Author: UPLOADED BY-ADMIN, BHUVANESWARI S, JOTHI G, RADHIKA J.
Abstract: The present study was conducted, to evaluate the antioxidant activity of the aqueous extract of Samanea saman (Jacq.) Merr. against carbontetrachloride (CCl4) induced liver toxicity in rats. The aqueous extract of Samanea saman (Jacq.) Merr.was administered orally to the albino rats with hepatotoxicity induced by CCl4 (0.5ml/ 150g). Silymarin (25mg/kg) was given as reference standard drug. The plant extract (250mg and 500mg/ kg b.w) were administered to the carbontetrachloride (CCl4) treated rats for 21days. Levels of lipid peroxide and reduced glutathione and activity of glutathione reductase, glutathione- S-transferase, glutathione peroxidase, Superoxide dismutase and catalase were evaluated. Oral administration of the aqueous extract of Samanea saman (Jacq.) Merr. significantly normalized the levels of lipid peroxide and reduced glutathione. Activity of glutathione reductase, glutathione-S-transferase, glutathione peroxidase, Superoxide dismutase and catalase were also resumed to normal. Results obtained indicates the antioxidant properties of Samanea saman (Jacq.) Merr. against carbontetrachloride (CCl4) –induced oxidative stress in rats.
Keyword: Samanea Saman, Carbon Tetrachloride, Glutathione Reductase, Antioxidant.
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