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Exploring Film Forming Potential of Curdlan in the Design of Regioselective Drug Delivery System of Ramipril
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| Author:
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GURAV YA, SAYYAD FJ, SUDKE SG
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| Abstract:
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The present investigation was based on the design of regioselective films for controlled release of Ramipril, a drug with narrow absorption window. The Ramipril loaded polymeric films of biological macromolecules, such as curdlan and pullulan were prepared using solvent casting method and fabricated into unit dosage form by folding and placing them into the hard gelatin capsules. The films were evaluated for average weight, thickness, folding endurance, uniformity of drug content etc. The drug release from films prepared with curdlan and pullulan respectively were compared with each other. The polymeric film revealed a fast drug release during the two hour followed by a more gradual drug release during a 12 h following a non-Fickian diffusion drug release mechanism. Various physical parameters were studied for evaluating their performance as a regioselective floating dosage form. The results revealed that the present regioselective drug delivery system grasps immense capability for absorption in proximal part of gastrointestinal tract.
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| Keyword:
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Curdlan, Pullulan, Regioselective, Ramipril, Gastrointestinal Tract, Non-Fickian diffusion
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.028
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| Download:
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