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Formulation of probiotics loaded granules of 5-Amino salicylic acid for colon targeting drug delivery system
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| Author:
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MUSTAFA KHAZIM, LAYTH JABBAR, SHAIMAA N. ABD AL HAMEED, NOOR M. HANOON
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| Abstract:
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In the present work, a probiotics loaded granules of 5-Amino salicylic acid (5-ASA) intended for efficient colon drug delivery system was formulated. Four polysaccharide biodegradable polymers (guar gum, pectin, starch, and chondroitin) were used which undergo enzymatic degradation in the colon to deliver the 5-ASA in the colon. Granules contain guar gum as biodegradable polymer and probiotic Lactobacillus fermentum were prepared by wet granulation method using different superdisintegrants, different ratio of gum to probiotics and different concentrations of coating material (shellac). The prepared granules were evaluated for flow properties using the compressibility index, also these granules were evaluated for its drug content, moisture content and in vitro drug release. The results showed that guar gum was the best biodegradable polymer, on the other hand Avicel PH-102 was the best superdisintegrant compared to others. The best ratio of gum to probiotics was 1:3 and the best concentration of coating material shellac was 10%. The results illusterated that the presence of bifidobacteria in the formulated granules coated with 10% shellac were able to retard the drug release for 6 hr then they released more than 80% of the drug in buffer of pH 6.8 at the end of 8th hour in the in vitro drug release studies. It can be concluded that the prepared granules of 5-ASA which contain guar gum and probiotic coated with 10% shellac have a good enteric property and may be used successfully for colon targeting to ensure maximum drug release at colon.
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| Keyword:
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5-Amino salicylic acid, Probiotics, colon targeting drug delivery system, Shellac, Avicel.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.045
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| Download:
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