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Preparation and In Vitro Evaluation of Clove Oil Microemulsion
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| Author:
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HAYDER K.ABBAS, QASIM A.BADER, AHMED H.HUSSEIN, DHURGHAM Q.SHAHEED
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| Abstract:
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Microemulsions (ME) are isotropic, thermodynamically stable structures holding a very high concentration of surfactant. Clove oil is essential oil extracted from Syzygium aromaticum which contains eugenol (80–88 %) with low eugenyl acetate and high content of caryophyllene. Nonionic surfactants (Tween in this case) as neutral particles likewise recognized as harmless and biocompatible produces; resist pH alterations in the medium. Cosurfactants are weak amphiphilic fragments which when used alone do not produce MEs, but they powerfully support gathering of the main surfactant. The aim of the current research to formulate clove oil based ME using Tween 20, Tween 80 and glycerin anhydrous as surfactant mixture in a ratio of (1:1). Clove oil and Smix were weighted into glass vials with the weight ratios of 1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 7:3, 8:2, and 9:1.The prepared formulations were evaluated for their physicochemical properties ( pH, particle size and particle size distribution, polydispersity index (PDI), emulsion typre was identified by dye solubility and conductivity test. Stability of ME was examined against freezing-thawing, centrifugation and heating cooling cycle. The results exhibit optimum particle size range from 7.88 – 176 nm for Tmix C3 and T20C8 respectively. pH values ranged from 4.1 – 4.8 and insignificant variation (p > 0.05) established in the original globule dimension for selected MEs that subjected to thermal stability and centrifugation protocols. As a conclusion, such ME possess a potentiality to be a suitable drug delivery system for wide range of the candidate drugs.
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| Keyword:
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eugenol
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.065
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| Download:
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