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Prodrug: Approach to Better Drug Delivery
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| Author:
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UPLOADED BY-ADMIN, VIKRAM LOHAR, SANDEEP SINGHAL, VIMAL ARORA
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| Abstract:
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Prodrugs as pharmacologically inactive chemical derivatives that could be used to alter the physiochemical properties of
drug in a temporary manner or to increase their usefulness and to decrease associated toxicity. A prodrug is compound
formed by chemical modification of biologically active compound that will liberate the active compound in vivo by enzymatic
or chemical processes. In both drug discovery and drug development, prodrugs have become an established tool for
improving physicochemical, biopharmaceutical or pharmacokinetic properties of pharmacologically active agents that
overcome barriers to a drug's usefulness. To illustrate the applicability of the prodrug strategy, this article describes the most
common functional groups that are amenable to prodrug design, and highlights examples of prodrugs that are either
launched or are undergoing human trials, strategies explored to date for site selective drug delivery, including CNS, Liver,
Kidney targeted drug delivery, Antibody based targeting, targeting the viruses, Anti HIV targeting, Colon targeting drug
delivery and novel approaches eg. prodrug incorporated delivery system including liposome, lipoprotein, emulsion and
solid lipid nanoparticles.
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| Keyword:
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Prodrug, Novel approaches, BBB, Colon targeted drug delivery
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| DOI:
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| Download:
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