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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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A brief review on recent advancement of solid lipid nanoparticle

Author: MANISHA MURALI, SUMALATDA DEVI BALAMURGAN, D.NAGASAMY VENKATESH
Abstract: Solid lipid nanoparticles (SLN) is wide applications in drug delivery, clinical medicine and in varied sciences and a novel technique. Its main advantage is that, it can improves the bioavailability and solubility of poorly soluble drugs. It can reduce the toxic effects of the drug, as biodegradable and bioacceptable polymers were used in the formulation. This review article gives an overview about solid lipid nanoparticle, which comprises different techniques used in the formulation and its evaluation such as differential scanning calorimetry(DSC),Transmission electron microscopy Scanning electron microscopy. This article briefly discusses about the benefit of solid lipid nanoparticle in therapeutic application. Moreover, this article discusses about overdosing effects of drugs and the way to overcome toxic effects using homogenization and solvent evaporation.
Keyword: Solid lipid nanoparticle, Solubility, Bioavailability, Biodegradable polymer, drug overdose.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.174
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