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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Myristica Fragrans seeds alleviate motor behavioural changes in rotenone model of parkinsons disease

Author: MUTHUVEL KANAGASABAPATHY, PRABHU KALIYAPERUMAL, RAJASANKAR SRINIVASAGAM
Abstract: Parkinson’s disease (PD) the second most common and progressive neurodegenerative disorder affecting the old aged people. PD caused due to the depletion of population of dopaminergic (DA) neurons in niagro striatal system of brain. Natural and synthetic substances such as 6-hydroxydopamine, Rotenone , 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Paraquat , LPS and cycad were ascertained to be neurotoxic, crossed the blood brain barrier and caused deleterious effects over Dopaminergic neurons. Rotenone (plant derived pesticide) inhibitor of complex I in mitochondrial electron transport chain causes dopaminergic neuron cell death. In the current study, we investigated the effect of MFSE against rotenone induced PD model in rats by behavioural parameters (open field test, narrow beam walking test, hanging test). Rats were administered rotenone by intra-peritoneal route (2.5mg/kg daily) 30days. MFSE treated rats alleviated rotenone induced motor behavioural impairments significantly. It might be due to its positive interaction between dopaminergic neurons mediated through its anti- inflammatory, anti-oxidant, anti- epileptic properties.
Keyword: Parkinsons Disease (PD), Nutmeg, Myristica fragrans , Rotenone (Rot)
DOI: https://doi.org/10.31838/ijpr/2020.12.03.176
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