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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evolution of Antibacterial efficacy of Dianthus caryophyllus L. extracts against some hospitals pathogenic bacteria

Author: SHIREEN KAMIL, HUSSEIN J. HUSSEIN, ALI H. AL-MARZOQI
Abstract: The current study was conducted to investigate the effect of phytochemical compounds extracted from flower buds of Dianthus caryophyllus L.by using three different solvents such as Ethanol, Acetone, and Hexane against some hospitals pathogenic bacteria in Iraq, such as Staphylococcus aureus, Enterobacter aerogenes, Enterococcus faecium, Pseudomonas aeruginosa, Enterococcus faecalis, and Escherichia coli. The antibacterial activity was performed by using agar well diffusion method against some hospitals pathogenic bacteria by preparing three concentrations (100, 200, and 400 mg/ml) for each extract. Dimethyl sulfoxide 10% was used as a negative control and different types of antibiotics based on the types of pathogenic bacteria as a positive control. Phytochemical compounds extracted by ethanol solvent at (400 mg/ml) showed significant superiority at (P= 0.05) over the Levofloxacin antibiotic when applied to E. aerogenes pathogenic bacteria. Phytochemical compounds extracted by acetone solvent at (400 mg/ml) showed significant superiority at (P= 0.05) over the Trimethoprim antibiotic when applied to E. faecalis pathogenic bacteria. Whereas, phytochemical compounds extracted by hexane solvent at (400 mg/ml) showed significant superiority at (P= 0.05) over the Levofloxacin antibiotic when applied to E. aerogenes and E. faecium pathogenic bacteria. Finally phytochemical compounds in flower buds of Dianthus caryophyllus L. regard a good source for controlling hospital pathogenic bacteria.
Keyword: Dianthus caryophyllus L, Antibacterial activity, Nosocomial infections.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.192
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