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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The role of Albumin infusion before exchange transfusion in term neonates with hyperbilirubinemia

Author: FARIS ALHARIS, AYMEN A. ALBAKAA, ALAA JUMAAH NASRAWI, ALI M. SHUAIB
Abstract: Background: Bilirubin is toxic substance to the central nervous system of neonates, so when neonates suffer from sever hyperbilirubinemia they need to be treated with phototherapy and even exchange transfusion. Objectives: is to detect the effects of intravenous infusion of human albumin before double volume exchange transfusion in rapid reduction of total serum bilirubin after exchange and in decreasing the risk of second time exchange. Patients and methods: A randomized control trial study done between January and December 2017 on fifty three neonates admitted to neonatal care unit of AL-Zahraa Teaching Hospital at AL-Najaf that fulfill the inclusion criteria and exclusion criteria. So two groups enrolled in the study as control group(n=29) and albumin group (n=24) , the albumin group receive albumin 1g/kg 20% one hour prior to exchange transfusion while in control group exchange transfusion only without albumin used. Results: A significantly lower mean post exchange total serum bilirubin in albumin group than that in control group at 6,12and 24 hours as p-value< 0.001 ,the mean of phototherapy duration significantly decreased in test group in comparison to control group (8.6±0.96hoursvs 17.9±3.8hours) respectively as p-value<0.001, also none of albumin group need second time exchange while three cases in control group underwent second time exchange with no side effects related to albumin use noticed. Conclusion: We conclude that Albumin administration before exchange blood transfusion can effectively reduces total serum bilirubin, period of phototherapy and greatly minimize risk of another exchange transfusion.
Keyword: Albumin, Hyperbilirubinemia, Exchange transfusion, jaundice.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.182
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