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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Eosinophil Level with Severity of Sepsis Based on Sequential Organ Failure Assessment Score

Author: IKE WIDURI, USMAN HADI, MUHAMMAD VITANATA ARFIJANTO
Abstract: Background: Eosinopenia may be used as an alternative sepsis biomarker, but the role of eosinopenia to predict the risk of mortality in sepsis patient is still controversial. This study aimed to analyze the association between eosinophil counts with severity of sepsis based on Sequential Organ Failure Assessment (SOFA) score. Methods: Study design was cross-sectional analytic on patients with sepsis. Patients were examined for eosinophil levels within the first 24 hours evaluated for SOFA scores. Results: A total of fourty patients were enrolled into this study. There were 23 males and 17 females, with the mean age of the subjects is 59.6±13.6 years old. The most common source of infection was soft tissue (47.5%), with the majority of comorbid factor being DM (67.5%). The median eosinophil count values in this study were 40 cells/µL (diff count) and 30 cells/µL (absolute eosinophil). The median score of SOFA scores in this study was 6.5. There were no correlation between eosinophil level (diff count and absolute eosinophil) and SOFA scores in sepsis patients (r = -0.145 and p = 0.374; r = -0.195 and p = 0.227, respectively). Conclusions: Eosinopenia was not a candidate marker for sepsis.
Keyword: Sepsis patient, eosinophil level, severity of sepsis, SOFA scores
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