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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Serum calcidiol level associated with axial spondyloarthritis disease activity

Author: HERU WIBOWO, AWALIA, JOEWONO SOEROSO
Abstract: Background: Vitamin D deficiency is frequent among axial spondyloarthritis (SpA) patients. However, the association between vitamin D level and axial SpA disease activity is still in debate. This study aimed to determine the correlation between serum calcidiol level and axial SpA disease activity. Methods: A cross-sectional study involving thirty axial SpA patients was conducted. All patients were diagnosed by rheumatologists according to the ASAS 2010 criteria. Axial SpA disease activities were measured using ASDAS-CRP score, and calcidiol level was examined using the ECLIA method. Results: The calcidiol levels had median value of 16.56 ng/ml (7.68-52 ng/ml). Calcidiol deficiency (<20 ng/ml) was found in 66.7% patients, calcidiol insufficiency (20-29.9 ng/ml) found in 16.7% patients, and normal level (=30 ng/ml) found in16.7% patients. Mean of ASDAS-CRP score was 3.36±0.96. Low disease activity was in 10% patients, high disease activity in 56.7% patients, and very high disease activity in 33.3% patients. There was significant correlation between calcidiol level and ASDAS-CRP score (r = -0.464, P = 0.01). Conclusion: Serum calcidiol level was significant negative correlated with axial SpA disease activity.
Keyword: Calcidiol, axial spondyloarthritis, disease activity, ASDAS-CRP, correlation
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