*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Effect of meloxicam and its metal [Zn(II), Cu(II), Co(II), Ni(II)] complexes on viability and/or proliferation of human non-small cell lung cancer cells

Author: LORA DYAKOVA, DANIELA-CRISTINA CULITA, TANYA ZHIVKOVA, MILENA GEORGIEVA, ROSSEN SPASOV, GEORGE MILOSHEV, RENI KALFIN, GABRIELA MARINESCU, LUMINITA PATRON, RADOSTINA ALEXANDROVA
Abstract: The purpose of the present investigations was to study the effect of selective non-steroidal anti-inflammatory agent meloxicam and its metal [Zn(II), Cu(II), Co(II), Ni(II)] complexes on viability and proliferation of cultured A549 human non-small cell lung cancer (NSCLC) cells. The investigations performed by thiazolyl blue tetrazolium bromide (MTT) test (the gold standard for cytotoxicity assay) revealed that applied at a concentration range of 5 – 500 µg/ml for 24h, 48h and 72h, the compounds examined express cytotoxic effect that is time- and concentration- dependent. Tested independently, meloxicam exhibits the lowest cytotoxicity. The effective concentrations of meloxicam and its metal complexes that reduce the amount of viable cells by 50% (CC50) as compared to the control (DMSO-control) were found to be lower in NSCLC A549 cells as compared to human non-tumor lung embryonic Lep-3 cells. Cu(II) complex of meloxicam was found to exhibit the highest cytotoxic activity that was further confirmed by double staining with acridine orange and propidium iodide, AnnexinV/FITC test and 3D colony-forming method.
Keyword: meloxicam, metal complexes, non-small cell lung cancer, cell cultures, cytotoxicity
DOI: https://doi.org/10.31838/ijpr/2020.12.03.216
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free