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Stomach-specific planning and analysis of sustained release floating in-situ gelling method for the distribution of anti-ulcer medication.
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| Author:
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VIJAYSINH SABLE, MAHESH K. GUPTA, NEETESH K. JAIN, GURDEEP SINGH
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| Abstract:
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Gastroretentive drug delivery is one of the main methods for prolonging gastric occupancy, peptic ulcer control and site-specific medication release enhancement for local or systemic effects in the upper gastrointestinal tract (GIT). Several approaches for the distribution of gastroretentive drugs have been planned and developed over the last few decades. We also developed oral sustained release in-situ floating gel as a carrier for the transmission of anti-nizatidine (NZD) unique to the stomach in present work. NZD is histamine H2-receptor antagonist. This is usually seen in extreme duodenal ulcers, stomach ulcers, heartburn, ulcerative esophagitis. Nonetheless, the recent inability of proton pump inhibitors to counteract the increase in gastric acid at night (related to elevated production in histamine at night) and side effects from certain H2 receptor antagonists (gyanacomastia) open up a different route to NZD transmission at particular periods in relation to the initiation of symptoms. Approximately 10 lots (F1-F10) were formulated and subjected to determination of f2 performance, viscosity (cps), gel strength (dyne / cm2), pH, product quality, and pharmacokinetic in vivo research. In-vivo experiments revealed a significant difference in the reduction of the ulcer index and the amount of gastric acid secretion from the formulation of nizatidine in situ gelling (for optimized batch F6) relative to the nizatidine solution (P < 0.01) and control group (P < 0.001). As a result, an efficient oral sustained release in-situ floating gel was developed and tested effectively as a carrier for stomach-specific distribution of anti Nizatidine.
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| Keyword:
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Nizatidine, Gellan gum, Oral Sustained Release, In-Situ Floating Gel.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.130
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| Download:
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